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Related Experiment Video

Updated: Sep 25, 2025

Folding and Characterization of a Bio-responsive Robot from DNA Origami
07:59

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

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Structure-flexible DNA origami translocation through a solid-state nanopore.

Jing Yang1,2, Nan Zhao1, Yuan Liang1

  • 1School of Control and Computer Engineering, North China Electric Power University Beijing 102206 China yjzcdd_2000@ncepu.edu.cn.

RSC Advances
|April 28, 2022
PubMed
Summary
This summary is machine-generated.

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Researchers studied flexible DNA origami structures using nanopore detection. Modulating origami flexibility altered translocation signals, offering new biosensing possibilities.

Area of Science:

  • Biophysics
  • Nanotechnology
  • Molecular Biology

Background:

  • Nanopore detection analyzes single molecules via translocation events.
  • Understanding DNA origami structural flexibility's impact on nanopore analysis is challenging.

Purpose of the Study:

  • To characterize the translocation of "nunchaku" DNA origami structures through solid-state nanopores.
  • To investigate how structural flexibility influences nanopore translocation signals.

Main Methods:

  • Utilized solid-state nanopores for single-molecule analysis.
  • Employed "nunchaku" DNA origami structures with tunable flexibility.
  • Regulated flexibility using specific DNA strands and streptavidin protein.

Main Results:

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Related Experiment Videos

Last Updated: Sep 25, 2025

Folding and Characterization of a Bio-responsive Robot from DNA Origami
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Design and Synthesis of a Reconfigurable DNA Accordion Rack
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Design and Synthesis of a Reconfigurable DNA Accordion Rack

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Designing a Bio-responsive Robot from DNA Origami
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  • Observed significant variations in translocation signals and distributions due to structural changes.
  • Demonstrated a correlation between DNA origami flexibility and nanopore translocation characteristics.

Conclusions:

  • Flexible DNA origami translocation through solid-state nanopores provides valuable insights into molecular behavior.
  • This method holds potential for advanced molecular detection and biosensing applications.