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Electrochemical synthesis of quinazolinone via I2-catalyzed tandem oxidation in aqueous solution
Huiqing Hou1, Xinhua Ma1, Yingying Lin1
1School of Pharmacy, Fujian Provincial Key Laboratory of Natural Medicine Pharmacology, Fujian Medical University Fuzhou 350004 China kefang@mail.fjmu.edu.cn +86-591-22862016 +86-591-22862016.
Abstract:
The development of protocols for synthesizing quinazolinones using biocompatible catalysts in aqueous medium will help to resolve the difficulties of using green and sustainable chemistry for their synthesis. Herein, using I2 in coordination with electrochemical synthesis induced a C-H oxidation reaction which is reported when using water as the environmentally friendly solvent to access a broad range of quinazolinones at room temperature. The reaction mechanism strongly showed that I2 cooperates electrochemically promoted the oxidation of alcohols, then effectively cyclizing amides to various quinazolinones.
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