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Related Experiment Video

Updated: Sep 25, 2025

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The Added Value of Patch Testing Beyond the Baseline Tray.

Dan Slodownik, Yehonatan Kaplan1, Eli Sprecher

  • 1From the Department of Dermatology, Tel Aviv Sourasky Medical Center.

Dermatitis : Contact, Atopic, Occupational, Drug
|April 28, 2022
PubMed
Summary
This summary is machine-generated.

Expanded patch testing significantly increases diagnoses of allergic contact dermatitis. Acrylate and fragrance sensitivities are common, with specific markers like 2-hydroxyethyl methacrylate proving valuable.

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Area of Science:

  • Dermatology
  • Allergology
  • Contact Dermatitis

Background:

  • Patch testing is the gold standard for diagnosing allergic contact dermatitis (ACD).
  • Standardized trays cover common allergens, while customized trays address specific allergens in specialized clinics.

Purpose of the Study:

  • To evaluate the diagnostic yield of expanded patch testing beyond the European baseline series (EBS).
  • To identify prevalent allergens outside the EBS and assess the number needed to treat (NNT) for relevant positive reactions.

Main Methods:

  • Analysis of 4355 patch tests conducted between 2012 and 2020 at a tertiary medical center.
  • Patients received the EBS and additional clinically indicated trays.
  • Assessment of positive reactions outside the EBS, focusing on added value and NNTs.

Main Results:

  • 21.9% of patients had relevant positive reactions; 43.3% tested positive for allergens outside the EBS.
  • Acrylate and fragrance trays showed high relevance (NNTs 4.4 and 6.8).
  • 2-Hydroxyethyl methacrylate was a key marker for acrylate sensitivity; patient's own medications yielded positive results in 10.9%.

Conclusions:

  • Expanded patch testing is essential, nearly doubling ACD diagnoses.
  • Acrylate and fragrance sensitivities are prevalent; 2-hydroxyethyl methacrylate is a reliable acrylate marker.
  • Testing patient's own medications and cosmetics is valuable; chloramphenicol warrants inclusion in standard trays where prevalent.