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Increased emergency cardiovascular events among under-40 population in Israel during vaccine rollout and third

Christopher L F Sun1,2, Eli Jaffe3,4, Retsef Levi5

  • 1Sloan School of Management, Massachusetts Institute of Technology, 100 Main Street, Cambridge, MA, 02142-1347, USA.

Scientific Reports
|April 28, 2022
PubMed

Insights

Emergency calls for cardiac arrest and acute coronary syndrome in young adults increased significantly following COVID-19 vaccination. This suggests potential cardiovascular vaccine side-effects warranting further investigation into vaccine safety surveillance.

Area of Science:

  • Public Health
  • Epidemiology
  • Cardiology

Background:

  • Cardiovascular adverse events are linked to COVID-19 infection and vaccines.
  • Enhancing vaccine safety surveillance with diverse data sources is crucial for understanding COVID-19 vaccine safety.
  • Emergency Medical Services (EMS) data offers a unique perspective on public health trends.

Purpose of the Study:

  • To evaluate the association between EMS call volumes for cardiac arrest and acute coronary syndrome in 16-39 year olds.
  • To explore potential links between these calls and COVID-19 infection rates and vaccination uptake in Israel.
  • To assess the utility of EMS data in identifying public health trends related to vaccine safety.

Main Methods:

  • Utilized a unique dataset from Israel National Emergency Medical Services (EMS) spanning 2019-2021.
  • Employed Negative Binomial regression models to analyze weekly emergency call counts.
  • Correlated call volumes with COVID-19 infection rates and COVID-19 vaccine administration rates (1st and 2nd doses) in the 16-39 age group.

Main Results:

  • A significant increase of over 25% in EMS calls for cardiac arrest and acute coronary syndrome was observed in January-May 2021 compared to 2019-2020.
  • Weekly emergency call counts were significantly associated with the rates of administered 1st and 2nd vaccine doses.
  • No significant association was found between emergency call counts and COVID-19 infection rates.

Conclusions:

  • Findings raise concerns about potential undetected severe cardiovascular side-effects from COVID-19 vaccines in young adults.
  • The study highlights the established causal link between vaccines and myocarditis, a cause of cardiac arrest.
  • Recommends incorporating EMS and other health data into surveillance systems to monitor vaccine safety and public health trends.

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