Interventions for obstructive uropathy in advanced prostate cancer: a population-based study.

Area of Science:

• Urology
• Oncology
• Health Informatics

Background:

• Upper tract obstructive uropathy (UTOU) is a complication in prostate cancer (PCa).
• Lack of population-based studies on UTOU incidence, treatment, and outcomes in PCa patients.
• Need for a validated method to identify UTOU interventions in administrative data.

Purpose of the Study:

• Develop and validate a coding framework to identify UTOU interventions.
• Utilize administrative hospital data for UTOU intervention assessment in PCa.
• Evaluate clinical outcomes associated with UTOU interventions in PCa.

Main Methods:

• Developed and validated a coding framework using procedural and diagnostic codes.
• Identified patients with newly diagnosed PCa (April 2014–March 2019) from the English cancer registry.
• Analyzed subsequent clinical outcomes using Hospital Episodes Statistics.

Main Results:

• Identified 77,010 locally advanced and 30,083 metastatic PCa patients.
• 1.8% of patients (1951) underwent UTOU intervention: 42.5% locally advanced, 57.5% metastatic.
• Cumulative incidence of intervention at 5 years: 4.2% for metastatic PCa vs. 1.4% for locally advanced PCa.

Conclusions:

• A novel coding framework effectively identifies UTOU interventions in PCa.
• 2% of locally advanced and 4% of metastatic PCa patients require UTOU intervention within 5 years.
• This framework enables large-scale studies on UTOU in PCa.