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Updated: Sep 25, 2025
Biomolecular Imaging of Cellular Uptake of Nanoparticles using Multimodal Nonlinear Optical Microscopy
Published on: May 16, 2022
Multimodal Imaging and Synergetic Chemodynamic/Photodynamic Therapy Achieved Using an NaGdF4 ,Yb,Er@ NaGdF4
Bo Ling1,2, Yaguang Wang3, Ruo Mi1
1Laboratory of Functionalized Molecular Solids, Ministry of Education Anhui Key Laboratory of Chemo/Biosensing Laboratory of Optical Probes and Bioelectrocatalysis (LOPAB) College of Chemistry and Materials Science, Anhui Normal University, Wuhu, 241002, P.R. China.
Abstract:
Here, NaGdF4 ,Yb,Er@NaGdF4 ,Yb,Tm@NaYF4 core@shell@shell three-layer structure of upconversion nanoparticles (UCNPs) coated with Fe-Tetrakis (4-carboxyphenyl) porphine (TCPP) metal-organic frameworks (Fe-MOFs) nanocomposite (UCNPs@MOFs) was designed and constructed for multimodal imaging and synergetic chemodynamic therapy (CDT)/photodynamic therapy (PDT) of tumors. The UCNPs@MOFs were successfully applied for tumor cells imaging in vitro and in vivo in near-infrared (NIR) region. The doped Gd was used as contrast agent for the magnetic resonance imaging (MRI) of mouse tumors. The luminescence in the UV-vis region was absorbed by the Fe-MOFs to produce singlet oxygen (1 O2 ) for PDT. The Fe3+ doped in the MOFs can catalyze H2 O2 to produce oxygen and hydroxyl radical (⋅OH). Hydroxyl radical is used in CDT and cooperates with the 1 O2 of PDT. Based on the CDT/PDT synergistic effects, the UCNPs@MOFs nanocomposite had obviously enhanced tumor inhibitory efficiency in vivo. These results described that the asprared UCNPs@MOFs nanocomposite have great potential in the effective multimodal imaging and treatment of tumors.
