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Complicated or non-complicated appendicitis? That is the question.
Tolga Dinç1, Ali Sapmaz1, Yasin Erkuş1
1Department of General Surgery, Ankara City Hospital, Ankara-Turkey.
Summary
Certain laboratory markers, including white blood cell count, neutrophil, monocyte, Delta neutrophil index (DNI), and bilirubin levels, can help differentiate complicated from non-complicated acute appendicitis.
Area of Science:
- General Surgery
- Emergency Medicine
- Clinical Pathology
Background:
- Acute appendicitis (AA) is a frequent cause of acute abdomen across all demographics.
- Distinguishing between complicated and non-complicated appendicitis pre-operatively is crucial for effective treatment.
- Identifying reliable laboratory markers for this distinction remains an area of clinical interest.
Purpose of the Study:
- To identify specific laboratory parameters that can differentiate complicated from non-complicated acute appendicitis in emergency department patients.
- To evaluate the diagnostic utility of various complete blood count and biochemical markers.
Main Methods:
- A retrospective study included male and female patients diagnosed with appendicitis between May 2019 and November 2020.
- Demographic data, complete blood counts (including Delta neutrophil index [DNI]), and biochemical parameters were collected.
- Patient parameters were compared between complicated and non-complicated appendicitis groups.
Main Results:
- Significantly elevated levels of white blood cell (WBC) count, monocyte, neutrophil, DNI, total bilirubin, and direct bilirubin were observed in the complicated appendicitis group.
- Statistical analysis confirmed the significance of these elevated markers (p-values <0.001 to 0.008).
Conclusions:
- Delta neutrophil index (DNI), bilirubin values, WBC, monocyte, neutrophil, and eosinophil show potential as laboratory indicators for distinguishing complicated from non-complicated appendicitis.
- These markers may aid in pre-operative assessment and management decisions for acute appendicitis.
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