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[hGH and molecular biology].

M Goossens

    Annales D'Endocrinologie
    |January 1, 1986
    PubMed
    Summary

    DNA recombinant technology advances our understanding of the human growth hormone (hGH) gene family. This review details the gene cluster

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    Area of Science:

    • Genetics and Molecular Biology
    • Endocrinology
    • Biotechnology

    Context:

    • The human growth hormone (hGH) gene family comprises five related genes on chromosome 17.
    • These genes share high sequence homology and are organized in a specific order.
    • Understanding this gene family is crucial for diagnosing and treating hGH deficiencies.

    Purpose:

    • To review recent advancements in understanding the hGH gene family using DNA recombinant technology.
    • To elucidate the molecular basis of human growth hormone deficiencies.
    • To detail the structure, organization, and evolutionary aspects of the hGH gene cluster.

    Summary:

    • The hGH gene cluster on chromosome 17 includes genes for hGH, human chorionic somatomammotropin (hCS), and a pseudogene.
    • The hGH-N gene encodes pituitary hGH, while hGH-V codes for a variant peptide.
    • hCS-A and hCS-B genes code for chorionic somatomammotropin, with differential placental expression; hCS-L is a pseudogene.

    Impact:

    • Provides a comprehensive overview of the hGH gene family structure and function.
    • Highlights the role of DNA recombinant technology in advancing genetic knowledge.
    • Facilitates research into growth disorders and the development of targeted therapies.

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