[Somatic cell hybridization as 1 of the mechanisms explaining the inadequacy of immunologic surveillance]

The literature analysis has shown that somatic cell hybridization is one of the mechanisms of tumour progression in vivo. This mechanism is suggested to underlie the establishment and development of human tumours, in particular of human breast cancer. Somatic hybridization of cells in human breast cancer is supposed to be one of the mechanisms responsible for the inadequacy of immunologic surveillance. The latter appears to occur in those cases when antigenic determinants of unchanged original cells predominate on the surface of hybrid formations.