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Updated: Sep 25, 2025

Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells
Published on: February 14, 2025
Advancing natural killer therapies against cancer
Emilie Narni-Mancinelli1, Eric Vivier2
1Aix Marseille Univ, CNRS, INSERM, CIML, Marseille, France.
Abstract:
Natural killer (NK)-based therapies against cancer are emerging, but the understanding of NK cell functions needs to be completed to optimize these treatments. In this issue, Pan et al. (2022) show that pro-apoptotic molecules, such as BH3-mimetics, synergize with NK cells to induce mitochondria-driven apoptosis in tumor cells, thereby enhancing the efficacy of NK cell therapies.
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