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Electrospun pullulan nanofiber loading zanthoxylum bungeanum essential oil/β-cyclodextrin inclusion complexes for
Zeyu Qin1, Yucheng Zou1, Yipeng Zhang1
1College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310058, China.
International Journal of Biological Macromolecules
|April 29, 2022
Summary
Zanthoxylum bungeanum essential oil/β-cyclodextrin inclusion complexes (ZBEO/β-CD-ICs) were prepared and incorporated into nanofibers. These ZBEO/β-CD-ICs enhanced thermal stability and antioxidant/antibacterial properties, showing potential for functional material applications.
Area of Science:
- Materials Science
- Food Science
- Biotechnology
Background:
- Zanthoxylum bungeanum essential oil (ZBEO) possesses valuable properties but requires stabilization for effective application.
- β-cyclodextrin (β-CD) is a common host molecule for forming inclusion complexes to improve the stability and delivery of active compounds.
Purpose of the Study:
- To prepare Zanthoxylum bungeanum essential oil/β-cyclodextrin inclusion complexes (ZBEO/β-CD-ICs).
- To fabricate nanofiber films incorporating ZBEO/β-CD-ICs using electrospinning.
- To evaluate the physicochemical properties, antibacterial, and antioxidant activities of the resulting nanofibers.
Main Methods:
- Preparation of ZBEO/β-CD-ICs via precipitation method.
- Fabrication of ZBEO/β-CD-IC-containing nanofiber films using electrospinning.
- Characterization using X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR).
- Assessment of antibacterial and antioxidant activities, and ZBEO release behavior.
Main Results:
- Optimal conditions for ZBEO/β-CD-IC preparation yielded high recovery (73.88%) and loading content (9.53%).
- Inclusion complexation improved thermal stability and altered crystalline structure.
- Nanofiber diameter and mechanical strength decreased with increasing ZBEO/β-CD-IC content, while thermal stability increased.
- XRD and FTIR confirmed enhanced crystallinity and hydrogen bonding in the films.
- Increased ZBEO content enhanced antibacterial and antioxidant efficacy, with Z40P10 nanofibers showing significant activity.
Conclusions:
- ZBEO/β-CD-ICs were successfully prepared and incorporated into electrospun nanofibers.
- The inclusion complexes enhanced the thermal stability and functional properties of the nanofibers.
- The developed nanofibers exhibit promising antibacterial and antioxidant activities, suggesting potential for applications in active packaging or biomedical fields.
