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Zinc and Kidney Disease: A Review
Ashkan Abdollahi1, Aria Ghahramani, Nasrollah Ghahramani
1Nephro-Urology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. ashkan.abdollahi@gmail.com.
Iranian Journal of Kidney Diseases
|April 30, 2022
Summary
Zinc deficiency is linked to chronic kidney disease (CKD) development and progression. Supplementation may benefit patients with kidney disease, particularly those on dialysis.
Area of Science:
- Nephrology
- Human Physiology
- Nutritional Science
Background:
- Zinc is a vital trace element crucial for cellular functions.
- Zinc deficiency is increasingly recognized as a factor in chronic kidney disease (CKD) and its complications.
- Dialysis exacerbates zinc loss, worsening deficiency in end-stage kidney disease (ESKD).
Purpose of the Study:
- To review the role of zinc deficiency in kidney disease.
- To explore the potential benefits of zinc supplementation in CKD patients.
Main Methods:
- Literature review of clinical and animal studies.
- Analysis of the correlation between zinc status and CKD progression.
- Evaluation of dietary intake's impact on zinc deficiency and CKD.
Main Results:
- Evidence suggests a causative link between zinc deficiency and CKD development and progression.
- Dietary factors significantly influence CKD risk and advancement in relation to zinc levels.
- Zinc deficiency is prevalent and worsened by dialysis in ESKD patients.
Conclusions:
- Zinc deficiency plays a significant role in the pathogenesis and progression of CKD.
- Zinc supplementation may be indicated across various stages of CKD.
- Further research into zinc's therapeutic potential in kidney disease is warranted.
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