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Both heat-sensitive TRPV4 and cold-sensitive TRPM8 ion channels regulate microglial activity.

Ranabir Chakraborty1, Chandan Goswami2

  • 1School of Biological Sciences, National Institute of Science Education and Research, Khurda, Odisha, 752050, India.

Biochemical and Biophysical Research Communications
|April 30, 2022
PubMed
Summary

Thermosensitive ion channels TRPV4 and TRPM8 are present in rat microglia. Modulating these channels impacts microglial cell functions, suggesting their role in brain health and disease.

Keywords:
Ca(2+)-signalingMicrogliaMigrationMotilityTRPM8TRPV4

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