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Updated: Sep 25, 2025
Magnetic Resonance Derived Myocardial Strain Assessment Using Feature Tracking
Published on: February 12, 2011
Dynamic Integrated Backscatter Detects Radiotherapy-induced Cardiac Changes Better than Strain Analysis - A
Suvi Sirkku Tuohinen1,2, Tanja Skytta3,4, Heini Huhtala5
1Heart and Lung Center, Helsinki University Central Hospital and Helsinki University, Helsinki, Finland; suvi.tuohinen@hus.fi.
Background/Aim:
Radiotherapy (RT) related myocardial changes were analyzed by deformation imaging echocardiography in this study.
Patients And Methods:
Ninety-nine breast cancer patients were studied at baseline, after chemotherapy, after RT, and three years after RT (3Y). Eighty patients received RT only, and twenty patients had right-sided breast cancer. Echocardiography included cyclic variation of the integrated backscatter in the septum (sCV) and posterior wall (pCV), global longitudinal strain (GLS), and left ventricular ejection fraction (LVEF).
Results:
In patients with left-sided breast cancer, sCV declined from 11.3±3.3 dB at baseline to 10.3±2.9 dB after RT (p=0.001). No changes were observed after chemotherapy (p=0.211) or in patients with right-sided breast cancer after RT (p=0.977). No other parameters declined after RT. The decline in sCV was independently associated with the left anterior descending coronary artery radiation dose (β=-0.290, p=0.020).
Conclusion:
In contrast to other parameters, sCV correlated with heart radiation dose.
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