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Updated: Sep 25, 2025

Author Spotlight: Membrane Protein Reconstitution in Synthetic Cells
Published on: March 8, 2024
Homecoming of the estranged GluD channels
Jamie A Abbott1, Gabriela K Popescu1
1Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, SUNY, 955 Main Street, Buffalo, NY 14203, USA.
Abstract:
A recent paper by Carrillo and colleagues demonstrates that GluD proteins form bona fide ligand-gated ion channels when their intrinsic flexibility is constrained by interactions with protein partners. Therefore, Delta receptors resemble all other members of the ionotropic glutamate receptor family not only by sequence and structural homology, but also by functional dynamics.
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