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Cancer-Associated Fibroblasts from Mouse Mammary Tumors as Tools for Molecular and Computational Studies
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Cancer.

Kristen D Kelley1, Paul Aronowitz2

  • 1Division of General Internal Medicine, UC Davis Heath, 4150 V Street, Suite 2400, Sacramento, CA 95817, USA.

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|May 1, 2022
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Summary
This summary is machine-generated.

Early cancer detection improves prognosis. This article highlights key physical examination findings, including lymphadenopathy, skin changes, and thrombosis, that may indicate underlying malignancy in patients.

Keywords:
CancerCushing diseaseDeep vein thrombosisLymphadenopathyMalignancyPhysical examinationSign of Leser-TrélatSweet syndrome

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Area of Science:

  • Oncology
  • Clinical Medicine
  • Diagnostic Physical Examination

Background:

  • Malignancy is a leading cause of death in the US.
  • Early cancer detection significantly impacts patient prognosis.
  • Recognizing physical signs of cancer is crucial for clinicians.

Purpose of the Study:

  • To review frequently encountered physical examination findings suggestive of malignancy.
  • To emphasize the importance of physical examination in early cancer detection.
  • To discuss specific findings such as lymphadenopathy, cutaneous manifestations, and thrombosis.

Main Methods:

  • Review of relevant medical literature on physical examination findings in oncology.
  • In-depth discussion of selected physical signs associated with various cancers.
  • Focus on practical, clinically relevant observations for healthcare providers.

Main Results:

  • Lymphadenopathy can indicate various hematologic and solid tumor malignancies.
  • Cutaneous findings, including specific lesions and changes, may be early signs of cancer.
  • Malignancy-associated thrombosis (e.g., Deep Vein Thrombosis) is a significant indicator.

Conclusions:

  • Physical examination remains a vital tool for identifying potential malignancy.
  • Awareness of specific findings like lymphadenopathy, skin changes, and thrombosis aids early diagnosis.
  • Prompt recognition of these signs can lead to earlier intervention and improved patient outcomes.