Automated synthesis of (R)-[¹⁸ F]MH.MZ on the iPhase Flexlab reaction platform

(R)-[¹⁸ F]MH.MZ ([¹⁸ F]MH.MZ) is a promising positron emission tomography (PET) radiotracer for in vivo study of the 5-HT_2A receptor. To facilitate clinical trials, a fully automated radiosynthesis procedure for [¹⁸ F]MH.MZ was developed using commercially available materials on the iPhase Flexlab module. The overall synthesis time was 100 min with a radiochemical yield of 7 ± 0.9% (n = 3). The radiochemical purity was greater than 99% for [¹⁸ F]MH.MZ with a molar activity of 361 ± 57 GBq/μmol (n = 3). The protocol described herein reliably provides [¹⁸ F]MH.MZ that meets all relevant release criteria for a GMP radiopharmaceutical.