Related Experiment Video
Updated: Jun 18, 2026
3D Printing of Preclinical X-ray Computed Tomographic Data Sets
Published on: March 22, 2013
Early Feasibility of Registration of Micro-PET/CT Scans to Annotated 3D Specimen Models
Joaquin Austerlitz1, Andreja Radevic1, Ashtyn McAdoo1,2,3
1Department of Otolaryngology - Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Background:
Intraoperative 18F-fluorodeoxyglucose (18F-FDG) micro-positron emission tomography/computed tomography (micro-PET/CT) is an emerging modality for margin assessment. Prior to clinical use, micro-PET/CT margin distances must be correlated with gold-standard histopathology.
Methods:
Micro-PET/CT uptake was co-registered to 3D specimen models annotated with margin sampling sites using principal component analysis and iterative closest point surface registration. Margin distances were measured on the fused models using Gaussian Mixed Modeling and compared with histopathology.
Results:
Fused micro-PET/CT and 3D specimen models were successfully generated for five patients with head and neck cancer. Among the 16 measured margins, the margin distance on the fused models was within 1 mm of histopathology in 15/16 cases. The Bland-Altman plot demonstrated excellent agreement (±1.25 mm).
Conclusion:
We report a novel technique to register micro-PET/CT data to annotated 3D specimen models. Margin distance measured on the micro-PET/CT scans correlated closely with histopathology. Intraoperative micro-PET/CT warrants further investigation in head and neck margin assessment.
More Related Videos
09:10Digital Hybrid Model Preparation for Virtual Planning of Reconstructive Dentoalveolar Surgical Procedures
Published on: August 5, 2021
07:57Scaled Anatomical Model Creation of Biomedical Tomographic Imaging Data and Associated Labels for Subsequent Sub-surface Laser Engraving (SSLE) of Glass Crystals
Published on: April 25, 2017