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Related Experiment Video

Updated: Sep 25, 2025

Fabrication of High Contact-Density, Flat-Interface Nerve Electrodes for Recording and Stimulation Applications
09:35

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Ultraflexible and Stretchable Intrafascicular Peripheral Nerve Recording Device with Axon-Dimension, Cuff-Less

Dongxiao Yan1, Ahmad A Jiman2,3, Elizabeth C Bottorff3

  • 1Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI, 48109, USA.

Small (Weinheim an Der Bergstrasse, Germany)
|May 2, 2022
PubMed
Summary
This summary is machine-generated.

A novel flexible microneedle nerve array (MINA) offers high-resolution peripheral nerve mapping. This technology minimizes chronic reactivity and enables cuff-free, suture-free implantation for advanced neuroscience research.

Keywords:
bioelectronicsintrafascicular recordingsmicroelectrode arraysmicroneedlesneural interfaces, peripheral nervestissue reactivity

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Materials Science

Background:

  • Advancing systems neuroscience requires peripheral nerve mapping tools with higher spatial resolution.
  • Microscale neural interfaces face challenges in application to small nerves and minimizing chronic reactivity.

Purpose of the Study:

  • To develop and evaluate a flexible microneedle nerve array (MINA) for high-density peripheral nerve recording.
  • To assess the acute and chronic performance and tissue response of the MINA system.

Main Methods:

  • Fabrication of a flexible microneedle nerve array (MINA) with axon-sized silicon microneedles.
  • Acute recording in the rat peroneal nerve and chronic implantation studies in the rat vagus nerve.
  • Histomorphometry and micro-CT imaging to quantify tissue response and encapsulation.

Main Results:

  • Distinctive neural units were identified in the rat peroneal nerve using MINA.
  • A novel light-activated adhesive (rose bengal) enabled cuff-free and suture-free MINA fixation.
  • MINA demonstrated reduced tissue encapsulation compared to interfascicular methods at 1 and 6 weeks.

Conclusions:

  • The flexible microneedle nerve array (MINA) is a promising high-density neural interface for peripheral nerve applications.
  • MINA shows reduced chronic reactivity and enables novel fixation techniques.
  • Further development is needed for precise microneedle insertion and long-term recording demonstration.