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Updated: Sep 25, 2025

Determination of Inorganic Arsenic in a Wide Range of Food Matrices using Hydride Generation - Atomic Absorption Spectrometry.
Published on: September 1, 2017
Chemical synthesis of the organoarsenical antibiotic arsinothricin
A Hasan Howlader1, Sazzad H Suzol1, Venkadesh Sarkarai Nadar2
1Department of Chemistry and Biochemistry, Florida International University Miami Florida 33199 USA wnuk@fiu.edu.
Abstract:
We report two routes of chemical synthesis of arsinothricin (AST), the novel organoarsenical antibiotic. One is by condensation of the 2-chloroethyl(methyl)arsinic acid with acetamidomalonate, and the second involves reduction of the N-acetyl protected derivative of hydroxyarsinothricin (AST-OH) and subsequent methylation of a trivalent arsenic intermediate with methyl iodide. The enzyme AST N-acetyltransferase (ArsN1) was utilized to purify l-AST from racemic AST. This chemical synthesis provides a source of this novel antibiotic for future drug development.
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