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Protective Roles of Apigenin Against Cardiometabolic Diseases: A Systematic Review

Yajie Xu1,2, Xue Li1, Hui Wang1

  • 1State Key Laboratory of Oncogenes and Related Genes, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Frontiers in Nutrition
|May 2, 2022
PubMed

Insights

Apigenin, a flavonoid, shows potential in treating cardiometabolic diseases like obesity and diabetes. Its effects vary by cell type, offering new therapeutic insights.

Area of Science:

  • Biochemistry
  • Pharmacology
  • Cardiovascular Research

Background:

  • Apigenin is a natural flavonoid with known antioxidant, anti-inflammatory, and anti-apoptotic properties.
  • Cardiometabolic diseases represent a significant global health burden.
  • Understanding the molecular mechanisms of natural compounds is crucial for developing new therapeutic strategies.

Purpose of the Study:

  • To investigate the potential effects of apigenin on cardiometabolic diseases.
  • To identify signaling networks and molecular mechanisms of apigenin in various cell types.
  • To analyze apigenin's role in obesity, diabetes, hypertension, and cardiovascular diseases.

Main Methods:

  • In vivo and in vitro experimental models were utilized.
  • Signaling pathways induced by apigenin were identified across different cell types.
  • Mechanisms of apigenin's biological response in various cardiometabolic conditions were analyzed.

Main Results:

  • Apigenin demonstrated potential effects on cardiometabolic disease models.
  • Cell-type-specific signaling networks were identified, indicating varied molecular mechanisms.
  • Apigenin's mechanisms were analyzed across obesity, diabetes, hypertension, and cardiovascular diseases.

Conclusions:

  • Apigenin exhibits therapeutic potential for cardiometabolic diseases.
  • The molecular mechanisms of apigenin are cell-type-dependent.
  • This review offers novel insights into apigenin's role in managing cardiometabolic health.
Keywords:
apigenincardiometabolic diseaseflavonoidmetabolic syndromesignaling pathways

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