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Related Experiment Video

Updated: Sep 25, 2025

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography
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Abnormal Large-Scale Neuronal Network in High Myopia.

Yu Ji1, Ling Shi1, Qi Cheng1

  • 1Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, China.

Frontiers in Human Neuroscience
|May 2, 2022
PubMed
Summary
This summary is machine-generated.

High myopia (HM) is associated with altered brain connectivity. Resting-state fMRI reveals significant changes in functional connectivity within and between brain networks in HM patients, impacting visual, cognitive, and motor functions.

Keywords:
functional connectivityfunctional network connectivityhigh myopiaindependent component analysisresting state network

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Area of Science:

  • Neuroscience
  • Radiology
  • Ophthalmology

Background:

  • High myopia (HM) is a significant public health concern.
  • Understanding the neural underpinnings of HM is crucial for developing effective interventions.

Purpose of the Study:

  • To investigate alterations in brain functional connectivity (FC) and functional network connectivity (FNC) in patients with high myopia (HM) using resting-state functional magnetic resonance imaging (rs-fMRI).

Main Methods:

  • rs-fMRI data were acquired from 82 HM patients and 59 healthy controls (HC).
  • Independent component analysis (ICA) was employed to extract 14 resting-state networks (RSNs).
  • FC within RSNs and FNC between RSNs were analyzed and compared between groups.

Main Results:

  • HM patients exhibited increased FC in visual, attention, auditory, and sensorimotor networks, and decreased FC in the default mode network (DMN).
  • Altered FC was observed in other networks, with both increases and decreases in specific brain regions.
  • Enhanced FNC was found between the DMN and the cerebellar network (CER) in HM patients.

Conclusions:

  • HM is associated with neural activity dysfunction within and between brain networks, particularly the DMN and CER.
  • These connectivity changes suggest potential deficits in visual processing, cognitive functions, and motor balance in individuals with high myopia.