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Topical Corticosteroid-Induced Adrenal Insufficiency: A Case Report
Nada Ghazi AlQadri1, Nouf Aljomah2, Hend M Alotaibi3
1College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
Case Reports in Dermatology
|May 2, 2022
Summary
Topical corticosteroids are generally safe but can cause rare systemic side effects. This case highlights adrenal insufficiency from topical corticosteroid use, emphasizing careful monitoring.
Area of Science:
- Dermatology
- Endocrinology
Background:
- Topical corticosteroids (TCS) are mainstays in dermatological treatment, widely used for their efficacy and safety profile when applied correctly.
- While local adverse effects are recognized, systemic toxicity is considered infrequent with appropriate usage.
- Understanding the risk-benefit ratio is crucial for optimizing dermatological therapy.
Observation:
- A case study detailing a patient's experience with topical corticosteroid (TCS) therapy.
- The patient presented with symptoms indicative of a serious systemic complication.
Findings:
- The patient developed secondary adrenal insufficiency, a rare systemic side effect attributed to the prolonged or extensive use of TCS.
- This finding underscores the potential for systemic absorption and subsequent endocrine disruption.
Implications:
- Highlights the importance of judicious prescribing and monitoring of TCS, even for topical applications.
- Suggests the need for increased awareness among clinicians regarding the potential for systemic side effects like adrenal insufficiency.
- Emphasizes patient education on proper application and duration to mitigate risks.
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