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The Spectrum of B Cell Functions in Atherosclerotic Cardiovascular Disease

Diede Smeets1, Anton Gisterå2,3, Stephen G Malin2,3

  • 1Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.

Frontiers in Cardiovascular Medicine
|May 2, 2022
PubMed

Insights

B cells play a dual role in atherosclerotic cardiovascular disease (ASCVD) pathogenesis, producing antibodies that can influence plaque development. Further research is needed to understand if atherosclerosis-specific antigens (ASA) instruct these B cell responses for targeted therapies.

Area of Science:

  • Immunology
  • Cardiovascular Science
  • Pathophysiology

Background:

  • B cells are integral to atherosclerotic cardiovascular disease (ASCVD) pathophysiology.
  • Studies show B cells have both protective and harmful effects on atherosclerotic plaque formation.
  • B cell antibody production is a key factor influencing atherosclerosis development.

Purpose of the Study:

  • To investigate the role of B cells in atherosclerotic cardiovascular disease (ASCVD).
  • To determine if atherosclerosis-specific antigens (ASA) guide B cell responses in atherosclerosis.
  • To explore novel therapeutic strategies for ASCVD by understanding B cell functions.

Main Methods:

  • Review of experimental and epidemiological studies on B cells in atherosclerosis.
  • Analysis of B cell homeostasis, differentiation, and antibody production in an atherogenic environment.
  • Investigation into the potential instruction of B cell responses by atherosclerosis-specific antigens (ASA).

Main Results:

  • B cells exhibit complex roles in atherosclerotic plaque development.
  • Antibody production by B cells is a significant factor in ASCVD.
  • The influence of atherosclerosis-specific antigens (ASA) on B cell responses remains unclear.

Conclusions:

  • Understanding the multifaceted roles of B cells in atherosclerosis is crucial.
  • Further research into atherosclerosis-specific antigens (ASA) and B cell interactions may yield new therapeutic targets.
  • Comprehensive analysis of B cell properties can lead to innovative treatments for ASCVD.

Keywords:
B cellsantibodiesatherosclerosiscardiovascular diseaseinflammationlipids

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