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Related Concept Videos

Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

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IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
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lncRNA - Long Non-coding RNAs02:39

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Experimental RNAi02:15

Experimental RNAi

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RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
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Types of RNA01:23

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Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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Alternative RNA Splicing02:18

Alternative RNA Splicing

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Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
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RNA Splicing01:32

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Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
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Related Experiment Video

Updated: Sep 25, 2025

Murine Model of Thoracic Aortic Dissection Induced by Oral &#946;-Aminopropionitrile and Subcutaneous Angiotensin II Infusion
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Murine Model of Thoracic Aortic Dissection Induced by Oral β-Aminopropionitrile and Subcutaneous Angiotensin II Infusion

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Non-coding RNAs Regulate the Pathogenesis of Aortic Dissection.

Yu-Yuan Hu1, Xin-Meng Cheng1, Nan Wu1

  • 1Division of Cardiovascular Surgery, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, China.

Frontiers in Cardiovascular Medicine
|May 2, 2022
PubMed
Summary

Aortic dissection (AD) is a deadly condition. This review explores how non-coding RNAs, like lncRNAs and circRNAs, contribute to AD, offering potential biomarkers and therapies.

Keywords:
aortic dissectionceRNA networknon-coding RNAspathogenesistherapeutic targets

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Area of Science:

  • Cardiovascular Research
  • Molecular Biology
  • Genetics

Background:

  • Aortic dissection (AD) is a life-threatening cardiovascular disease with high mortality.
  • Current understanding of AD pathogenesis remains incomplete, necessitating new research avenues.
  • Non-coding RNAs (ncRNAs) are emerging regulators of gene expression with potential roles in disease.

Purpose of the Study:

  • To review the current knowledge on the role of various ncRNAs in AD pathogenesis.
  • To discuss the potential of ncRNAs as clinical biomarkers and therapeutic targets for AD.
  • To identify limitations in current evidence and suggest future research directions.

Main Methods:

  • Literature review of studies on non-coding RNAs (microRNAs, lncRNAs, circRNAs) in aortic dissection.
  • Synthesis of existing data on the molecular mechanisms of ncRNAs in AD.
  • Analysis of the potential clinical applications of ncRNAs in AD diagnosis and treatment.

Main Results:

  • Non-coding RNAs, including microRNAs, lncRNAs, and circRNAs, play significant roles in AD pathogenesis.
  • These ncRNAs regulate gene expression and are implicated in the molecular mechanisms underlying AD.
  • Emerging evidence highlights their potential as diagnostic biomarkers and therapeutic targets for AD.

Conclusions:

  • Non-coding RNAs represent a promising area for understanding and treating aortic dissection.
  • Further research is needed to fully elucidate the roles of lncRNAs and circRNAs in AD and translate findings into clinical practice.
  • Developing ncRNA-based strategies could significantly improve outcomes for patients with AD.