Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Jasmonic acid and PpeMYC2 regulate peach fruit ripening by controlling polyamine levels and anthocyanin biosynthesis.

Plant physiology·2026
Same author

Abundance of <i>Yersinia pestis</i> Nucleic Acids in Soil from <i>Rattus tanezumi</i> Plague Foci in Yunnan Using ddPCR.

Pathogens (Basel, Switzerland)·2026
Same author

In vitro digestion and fermentation characteristics of ethanol-extracted low molecular weight ginseng polysaccharide (AGP): Interactions with gut microbiota, metabolite regulation, and immunomodulatory effects.

Food research international (Ottawa, Ont.)·2026
Same author

LncRNA7503 decreases peach (Prunus persica) branch number and angle by inducing pre-miR395a degradation and reducing bioactive BR content.

Molecular horticulture·2026
Same author

PpBRC1 negatively regulates branching via modulating GA signal transduction gene PpGID1b in peach (Prunus persica).

Plant cell reports·2026
Same author

Isolation and Characterization of Two Bacteriophages Infecting <i>Bacillus anthracis</i>: Biological Properties and Genomic Analysis.

Microorganisms·2026
Same journal

A programmable benchtop photocrosslinking chamber for controlled bioconjugation.

HardwareX·2026
Same journal

Design of an onboard computer for small experimental rockets with an integrated hardware-in-the-loop validation framework.

HardwareX·2026
Same journal

Corrigendum to "An alternative linear impactor for impact research" [HardwareX 25 (2026) e00742].

HardwareX·2026
Same journal

Low-cost embedded system for spectral power distribution reconstruction for controlled environmental agriculture using a multispectral sensor and cloud-based deep learning.

HardwareX·2026
Same journal

Octopus: A low-cost, modular environmental sensing platform for makers.

HardwareX·2026
Same journal

Open Diagnostic Reader (ODR): An affordable, modular 3D-printed platform for standardized imaging and quantitative analysis of rapid diagnostic tests.

HardwareX·2026
See all related articles

Related Experiment Video

Updated: Sep 25, 2025

An Additive Manufacturing Technique for the Facile and Rapid Fabrication of Hydrogel-based Micromachines with Magnetically Responsive Components
08:17

An Additive Manufacturing Technique for the Facile and Rapid Fabrication of Hydrogel-based Micromachines with Magnetically Responsive Components

Published on: July 18, 2018

7.3K

Rotating-liquid-based hydrogel bead generator.

Haipeng Zhang1, Sangjin Ryu1,2

  • 1Department of Mechanical & Materials Engineering, University of Nebraska-Lincoln, Lincoln, Nebraska 68588, USA.

Hardwarex
|May 2, 2022
PubMed
Summary
This summary is machine-generated.

We developed a simple, low-cost, open-source hydrogel bead generator. This device uses rotating immiscible liquids to create uniform hydrogel beads, offering an accessible alternative to complex equipment for various applications.

Keywords:
AlginateContinuous phaseCross flowDispersed phaseDripping modeDrop generationJetting mode

More Related Videos

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning
12:07

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Published on: April 16, 2018

13.6K
Multi-step Variable Height Photolithography for Valved Multilayer Microfluidic Devices
10:18

Multi-step Variable Height Photolithography for Valved Multilayer Microfluidic Devices

Published on: January 27, 2017

14.5K

Related Experiment Videos

Last Updated: Sep 25, 2025

An Additive Manufacturing Technique for the Facile and Rapid Fabrication of Hydrogel-based Micromachines with Magnetically Responsive Components
08:17

An Additive Manufacturing Technique for the Facile and Rapid Fabrication of Hydrogel-based Micromachines with Magnetically Responsive Components

Published on: July 18, 2018

7.3K
Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning
12:07

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Published on: April 16, 2018

13.6K
Multi-step Variable Height Photolithography for Valved Multilayer Microfluidic Devices
10:18

Multi-step Variable Height Photolithography for Valved Multilayer Microfluidic Devices

Published on: January 27, 2017

14.5K

Area of Science:

  • Materials Science
  • Chemical Engineering
  • Biotechnology

Background:

  • Hydrogel beads are essential in diverse fields, but their production often involves complex and expensive equipment.
  • Existing methods pose challenges in terms of accessibility and cost-effectiveness for widespread adoption.

Purpose of the Study:

  • To introduce an easy-to-adopt, cost-effective, and open-source hydrogel bead generator.
  • To demonstrate a novel method for producing uniform hydrogel beads without specialized devices.

Main Methods:

  • The generator utilizes two modules: one for rotating immiscible liquids (mineral oil and cross-linking solution) and another for injecting the hydrogel pre-polymer solution.
  • Drops of the dispersed phase (pre-polymer) are formed and pinched off by shear forces in the continuous phase (oil) before settling into the cross-linking liquid to form beads.
  • Control over bead size is achieved by adjusting the flow rates of the continuous and dispersed phase liquids.

Main Results:

  • The proposed generator successfully produced hydrogel beads of uniform size and shape.
  • Experiments confirmed that adjusting liquid flow speeds effectively controls the size of the generated drops.
  • Alginate gel beads were successfully fabricated, demonstrating the generator's practical applicability.

Conclusions:

  • The developed open-source hydrogel bead generator offers a simple, affordable, and effective solution for producing uniform hydrogel beads.
  • This technology has the potential to democratize hydrogel bead production for research and industrial applications.
  • The ease of use and low cost make it suitable for various scientific and technological applications requiring hydrogel beads.