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Published on: September 1, 2023
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Extracellular vesicles-mediated interaction within intestinal microenvironment in inflammatory bowel disease
Qichen Shen1, Zhuizui Huang1, Jiachen Yao2
1Department of Biotechnology, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310032, China.
Journal of Advanced Research
|May 2, 2022
Summary
Extracellular vesicles (EVs) modulate the gut environment, offering potential for inflammatory bowel disease (IBD) treatment. These vesicles aid in immune response and microbial balance, paving the way for novel IBD therapies.
Area of Science:
- Gastroenterology
- Immunology
- Cell Biology
Background:
- The intestinal tract is a complex ecosystem maintained by host-microbiota interactions.
- Inflammatory bowel disease (IBD) involves chronic intestinal inflammation and microbial imbalance (dysbiosis).
- Extracellular vesicles (EVs) are crucial for cell communication and maintaining intestinal homeostasis.
Purpose of the Study:
- To review the modulatory functions of extracellular vesicles (EVs) from various sources within the intestine.
- To discuss the effects and therapeutic applications of EVs in clinical inflammatory bowel disease (IBD) therapy.
- To elucidate EV-mediated host-microbiota interactions in IBD pathogenesis and treatment.
Main Methods:
- Literature review focusing on extracellular vesicles (EVs) in the context of inflammatory bowel disease (IBD).
- Analysis of studies detailing EV-mediated communication between host intestine and microbiota.
- Examination of evidence for EVs in regulating immune responses and microbial communities in the gut.
Main Results:
- EVs facilitate communication between the host intestine and its microbiota.
- EVs act as regulators in inflammatory conditions, promoting immune responses and microbial reconstruction.
- EVs demonstrate potential as therapeutic delivery vehicles for genetic material.
Conclusions:
- Extracellular vesicles (EVs) play a significant role in modulating the intestinal microenvironment.
- EVs offer promising therapeutic strategies for inflammatory bowel disease (IBD) by restoring microbial balance and immune function.
- EV-based immunotherapy represents a potential future treatment for IBD.
Keywords:
ANXA1, Annexin A1BMSC, bone marrow mesenchymal stem cellCD, Crohn’s diseaseCMVs, Cytoplasmic membrane vesiclesCRC, Colorectal cancerDSS, Dextran sulfate sodiumE-cadherin, Epithelial cadherin. EMT, Epithelial-mesenchymal transitionE. coli, Escherichia coliECN, E. coli strain Nissle 1917EVs, Extracellular vesiclesExtracellular vesiclesFMT, Fecal microbiota transplantationGI, GastrointestinalIBD, Inflammatory bowel diseaseIECs, Intestinal epithelial cellsInflammatory bowel diseaseIntestinal barrierLPS, lipopolysaccharideMSC, Marrow-derived mesenchymal stromal cellsMVs, Membrane vesiclesMicrobiotaNEAT1, Nuclear paraspeckle assembly transcript 1OMVs, Outer-membrane vesiclesPSMA7, proteasome subunit alpha type 7SCFA, Short-chain fatty acidTJs, tight junctionsTLR, Toll-like receptorTNBS, 2,4,6-trinitrobenzenesulfonic acidTherapyTreg, Regulatory T cellUC, Ulcerative colitishucMSC, Human umbilical cord MSCMore Related Videos
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