Computational modeling of poroelastic brain tumor therapy during heat transfer carrying temperature-dependent blood...

In this research paper, an alternative treatment protocol based on modeling and simulation approach contrary to costly and time-consuming in vivo and in vitro studies is developed for thermal therapy of poroelastic brain tumors. Instead of constant blood perfusion, the time-dependent blood perfusion is incorporated in Penne's bio-heat transfer model to investigate its behavior both in the normal and tumor tissues. The impact of parameters of amplitude and frequency of the applied magnetic field on the heating effect is investigated. All the coupled hyperthermia processes based on finite element method-based models are simulated and analyzed quantitatively using COMSOL Multiphysics software. Temperature-dependent blood perfusion increases in healthy tissue and decreases in cancerous tissue. The infusion pressure, infusion velocity, concentration, tumor temperature, and the fraction of tumor damage are maximum at the tumor center, and these decrease in moving from the center of the tumor to the radial outward direction.