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Changes in Kidney Graft Function in COVID-19 Convalescents
Agnieszka Malinowska1, Zbigniew Heleniak1, Marta Muchlado1
1Department of Nephrology, Transplantology and Internal Medicine, Medical University of Gdańsk, Gdańsk, Poland.
Transplantation Proceedings
|May 2, 2022
Summary
Kidney transplant recipients with mild COVID-19 showed no negative impact on graft function six months post-recovery. This study assessed long-term kidney transplant outcomes after SARS-CoV-2 infection.
Area of Science:
- Nephrology
- Infectious Diseases
- Transplantation Immunology
Background:
- Kidney transplant recipients (KTRs) face elevated risks from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
- Limited data exists on COVID-19's long-term impact on graft function in KTR convalescents.
- This study aimed to assess COVID-19's effect on graft function at six months post-recovery.
Purpose of the Study:
- To evaluate the influence of COVID-19 on kidney graft function in transplant recipients.
- To determine if a mild SARS-CoV-2 infection impacts long-term kidney transplant outcomes.
Main Methods:
- A longitudinal controlled study included 77 kidney transplant recipients (KTRs) with a history of COVID-19.
- Data on serum creatinine levels were collected pre-infection and six months post-recovery.
- Stratified analysis considered comorbidity and fragility scores.
Main Results:
- No significant difference in serum creatinine levels was observed six months after COVID-19 compared to pre-infection levels.
- Creatinine concentrations did not differ between KTRs and controls.
- No impact on graft function was found across different comorbidity and fragility strata.
Conclusions:
- Mild COVID-19 in kidney transplant recipients did not negatively affect graft function six months after recovery.
- Long-term graft function appears preserved in KTRs following a mild SARS-CoV-2 infection.
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