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Updated: Sep 24, 2025

In Vitro Analysis of E3 Ubiquitin Ligase Function
Published on: May 14, 2021
The role of K63-linked polyubiquitin in several types of autophagy
1Department of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, Budapest, Hungary.
Abstract:
Lysosomal-dependent self-degradative (autophagic) mechanisms are essential for the maintenance of normal homeostasis in all eukaryotic cells. Several types of such self-degradative and recycling pathways have been identified, based on how the cellular self material can incorporate into the lysosomal lumen. Ubiquitination, a well-known and frequently occurred posttranslational modification has essential role in all cell biological processes, thus in autophagy too. The second most common type of polyubiquitin chain is the K63-linked polyubiquitin, which strongly connects to some self-degradative mechanisms in the cells. In this review, we discuss the role of this type of polyubiquitin pattern in numerous autophagic processes.
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