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Targeting XPO1-Dependent Nuclear Export in Cancer

Ekaterina Kim1, Daria A Mordovkina2, Alexey Sorokin3

  • 1The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. ekim3@mdanderson.org.

Biochemistry. Biokhimiia
|May 3, 2022
PubMed

Insights

Exportin 1 (XPO1) protein export is crucial for cells. Inhibiting XPO1 shows promise in treating various cancers, with ongoing clinical trials evaluating its effectiveness.

Area of Science:

  • Cell biology
  • Molecular biology
  • Oncology

Background:

  • Nucleocytoplasmic transport is vital for eukaryotic cells.
  • Exportin 1 (XPO1) mediates the export of numerous proteins and RNAs.
  • Increased XPO1 levels and mutations are linked to cancer progression and poor prognosis.

Purpose of the Study:

  • To review the functions of XPO1.
  • To discuss the role of XPO1 in cancer development.
  • To summarize recent clinical trial outcomes for XPO1 inhibitors.

Main Methods:

  • Literature review of XPO1 functions.
  • Analysis of XPO1's role in oncogenesis.
  • Summary of preclinical and clinical data for XPO1 inhibitors.

Main Results:

  • XPO1 is essential for exporting key cellular components.
  • Dysregulation of XPO1 is implicated in multiple cancer types.
  • Novel small-molecule XPO1 inhibitors have shown efficacy in preclinical and clinical studies.

Conclusions:

  • XPO1 is a significant factor in cancer biology.
  • Targeting XPO1 with inhibitors represents a promising therapeutic strategy.
  • Ongoing clinical trials are evaluating the potential of XPO1 inhibitors in cancer treatment.
Keywords:
SINEXPO1cancernuclear exportselinexor

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