CMTM Family and Gastrointestinal Tract Cancers: A Comprehensive Review

Area of Science:

• Oncology
• Molecular Biology
• Immunology

Background:

• Gastrointestinal tract cancers represent a significant global health burden.
• The Chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing family (CMTMs) is implicated in various cancers.
• CMTM family members have demonstrated roles in cancer development, progression, and antitumor immunity.

Purpose of the Study:

• To systematically review the current literature on the role of the CMTM family in gastrointestinal tract cancers.
• To highlight the prognostic value and immunological functions of CMTMs in these malignancies.
• To focus on the specific roles of CMTMs in hepatocellular carcinoma and gastric carcinoma.

Main Methods:

• Systematic literature review.
• Analysis of studies investigating CMTM family members in gastrointestinal cancers.
• Focus on hepatocellular carcinoma and gastric carcinoma research.

Main Results:

• The CMTM family exhibits significant prognostic potential across multiple cancers.
• Altered expression of CMTM members correlates with advanced tumor stage, metastasis, and survival outcomes.
• CMTM proteins are involved in critical aspects of the antitumor immune response.

Conclusions:

• The CMTM family plays a crucial role in the development and progression of gastrointestinal tract cancers.
• CMTMs hold promise as prognostic biomarkers and therapeutic targets in gastrointestinal oncology.
• Further research into CMTM functions can advance understanding of gastrointestinal cancer biology and immunity.