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Related Concept Videos

Asthma-I: Introduction01:29

Asthma-I: Introduction

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Asthma: Pathogenesis and Management01:20

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
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Asthma-III: Symptoms and Complications01:24

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Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
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Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

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Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
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COPD: Pathogenesis and Clinical Features01:20

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Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
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Updated: Sep 24, 2025

Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes
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Obesity is a risk factor for decrease in lung function after COVID-19 infection in children with asthma.

Elif Soyak Aytekin1, Umit M Sahiner1, Sevda Tuten Dal1

  • 1Department of Pediatric Allergy, Hacettepe University School of Medicine, Ankara, Turkey.

Pediatric Pulmonology
|May 3, 2022
PubMed
Summary
This summary is machine-generated.

COVID-19 infection can cause small airway dysfunction in children with asthma. Obesity is a key risk factor for this decline, highlighting the need for monitoring these children long-term.

Keywords:
COVID-19asthmachildhoodobesitysmall airway dysfunction

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Area of Science:

  • Pediatric Pulmonology
  • Infectious Diseases
  • Asthma Research

Background:

  • Asthma is a common childhood chronic disease.
  • The impact of SARS-CoV-2 (the virus causing COVID-19) on pediatric asthma patients' lung function remains unclear.
  • Understanding these effects is crucial for managing respiratory health in children.

Purpose of the Study:

  • To investigate the clinical course and consequences of COVID-19 in children with asthma.
  • To identify risk factors associated with decreased lung function tests (LFTs) post-COVID-19 infection.
  • To evaluate the specific effects of SARS-CoV-2 on lung function in pediatric asthma patients.

Main Methods:

  • A retrospective study comparing asthmatic children with and without COVID-19.
  • Analysis of clinical data and lung function tests (LFTs) before and after COVID-19 infection.
  • Identification of independent risk factors for significant decline in specific LFT parameters.

Main Results:

  • 189 asthmatic children with COVID-19 and 792 without were analyzed.
  • Most COVID-19 cases were mild (87.6%); severe outcomes like MIS-C and pneumothorax were rare.
  • While overall LFTs (FEV1%, FVC%, FEV1/FVC) showed no significant change, FEF25%-75% significantly decreased post-COVID-19.
  • Obesity and a family history of atopy were identified as independent risk factors for a ≥25% decrease in FEF25-75.

Conclusions:

  • COVID-19 infection can lead to small airway dysfunction in children with asthma.
  • Obesity is a significant independent risk factor for reduced small airway function after COVID-19.
  • Long-term monitoring of small airway function is essential for asthmatic children post-COVID-19 infection.