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Updated: Sep 24, 2025

Osteoclast Derivation from Mouse Bone Marrow
Published on: November 6, 2014
The origins and roles of osteoclasts in bone development, homeostasis and repair
Yasuhito Yahara1,2,3, Tuyet Nguyen1,4, Koji Ishikawa1,5
1Department of Orthopaedic Surgery, Duke University School of Medicine, Durham, NC 27710, United States.
Abstract:
The mechanisms underlying bone development, repair and regeneration are reliant on the interplay and communication between osteoclasts and other surrounding cells. Osteoclasts are multinucleated monocyte lineage cells with resorptive abilities, forming the bone marrow cavity during development. This marrow cavity, essential to hematopoiesis and osteoclast-osteoblast interactions, provides a setting to investigate the origin of osteoclasts and their multi-faceted roles. This Review examines recent developments in the embryonic understanding of osteoclast origin, as well as interactions within the immune environment to regulate normal and pathological bone development, homeostasis and repair.
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