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Expression of Tissue microRNAs in Ascending Aortic Aneurysms and Dissections

Athina Goliopoulou1, Evangelos Oikonomou1, Alexis Antonopoulos2

  • 13rd Department of Cardiology, National and Kapodistrian University of Athens, Medical School, "Sotiria" Chest Disease Hospital, Athens, Greece.

Angiology
|May 3, 2022
PubMed

Insights

MicroRNAs, not matrix metalloproteinases, are implicated in ascending aortic aneurysms and dissections. Elevated microRNA-29 and microRNA-195 suggest their role in disease progression and potential as therapeutic targets.

Area of Science:

  • Cardiovascular Biology
  • Molecular Medicine
  • Aortic Disease Research

Background:

  • The molecular mechanisms driving ascending aortic aneurysms and dissections remain incompletely understood.
  • Investigating serum and tissue mediators is crucial for understanding disease pathogenesis.

Purpose of the Study:

  • To evaluate the association of tissue microRNAs (miRNAs) and matrix metalloproteinases (MMPs) with ascending aortic aneurysms and dissections.
  • To assess serum levels of osteoprotegerin, adiponectin, and high sensitivity C-reactive protein (hsCRP) in these conditions.

Main Methods:

  • Comparative analysis of serum biomarkers and tissue expression of specific miRNAs and MMPs in patients with aortic aneurysm, aortic dissection, and healthy controls.
  • Quantitative assessment of tissue miRNA-29, miRNA-195, MMP-2, and MMP-9 expression.
  • Measurement of serum osteoprotegerin, adiponectin, and hsCRP levels.

Main Results:

  • Serum levels of osteoprotegerin, adiponectin, and tissue expression of MMP-2 and MMP-9 showed no significant differences between groups.
  • Higher hsCRP levels were observed in the aortic dissection group compared to controls.
  • Tissue expression of miRNA-29 was significantly elevated in both aneurysm and dissection groups, while miRNA-195 was higher in the dissection group and lower in the aneurysm group compared to controls.

Conclusions:

  • MicroRNAs play a significant role in the progression of ascending aortic aneurysms and dissections.
  • Specific miRNAs, such as miRNA-29 and miRNA-195, show altered expression patterns in these aortic diseases.
  • These findings highlight miRNAs as potential diagnostic biomarkers and therapeutic targets for aortic pathologies.
Keywords:
aortic aneurysmmatrix metalloproteinasesmicroRNA

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