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Related Experiment Video

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Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

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Published on: May 31, 2016

Association between Periodontitis and Aortic Calcification: A Cohort Study.

Ying-Lin Yu¹, Jun-Rong Ma¹, Shu-Na Li¹

¹Department of Epidemiology, School of Medicine, 47885Jinan University, Guangdong, China.

|May 3, 2022

Summary

Periodontitis, a gum disease, is linked to increased aortic calcification (AC) risk in Chinese adults. This association is stronger in males and individuals under 65, highlighting a potential cardiovascular connection.

Keywords:

age aortic calcification cardiovascular risk gender outcome risk factors

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Published on: February 4, 2021

Area of Science:

Cardiovascular Health
Oral Health
Public Health

Background:

Periodontitis is a common oral inflammatory condition.
Aortic calcification (AC) is a marker of cardiovascular disease.
The link between periodontitis and AC requires further investigation in diverse populations.

Purpose of the Study:

To investigate the association between periodontitis and the risk of developing aortic calcification (AC) among Chinese adults.
To identify specific demographic groups within the Chinese adult population where this association may be more pronounced.

Main Methods:

A cohort of 6059 Chinese adults diagnosed with periodontitis between 2009-2016 was analyzed.
Aortic calcification (AC) was assessed using low-dose spiral CT scans.
Cox proportional hazards regression models were employed to evaluate the association, adjusting for confounders.

Main Results:

Over a median follow-up of 2.3 years, 843 cases of AC were identified.
Participants with periodontitis had a significantly higher risk of AC (HR 1.18, 95% CI 1.02-1.36, P=.025) compared to those without.
The positive association between periodontitis and AC was more pronounced in males and individuals younger than 65 years.

Conclusions:

Periodontitis is independently associated with an increased risk of aortic calcification in Chinese adults.
The findings suggest that periodontitis may contribute to subclinical atherosclerosis, particularly in younger males.
These results underscore the importance of managing oral health for cardiovascular disease prevention.