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[Endogenous counterinflammation and immunostimulation].

R M Fauve

    Pathologie-Biologie
    |February 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Inflammation triggers a remote anti-inflammatory response, termed counterinflammation, in mice. This response enhances host resistance to pathogens and tumor cells, mediated by novel endogenous substances called phlogautacoïds.

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    Area of Science:

    • Immunology
    • Pathology
    • Pharmacology

    Context:

    • Inflammation is crucial for pathogen resistance at the site of infection.
    • Recent findings reveal beneficial inflammatory effects at remote sites.
    • A counterinflammatory response, reducing inflammation distally, has been identified.

    Purpose:

    • To investigate the nature and effects of counterinflammation in mice.
    • To identify endogenous mediators of enhanced host resistance during inflammation.
    • To characterize novel immunostimulatory proteins involved in host defense.

    Summary:

    • Counterinflammation in mice, observed 6 hours post-primo-inflammation, rivals glucocorticoids in potency.
    • This response is T lymphocyte-independent and does not involve arachidonic acid metabolites.

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  • Increased host resistance against diverse pathogens and tumor cells emerges 3-10 days later.
  • A purified 56 kDa protein, similar to interferon gamma, acts as a potent immunostimulant.
  • Other effectors, including hematopoiesis and cytostasis proteins, are under investigation.

    • Impact:

    • Identifies phlogautacoïds as potent endogenous drugs with therapeutic potential.
    • Suggests novel strategies for modulating immune responses and enhancing host defense.
    • Provides insights into the complex systemic effects of localized inflammation.