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A Closed-Type Wireless Nanopore Electrode for Analyzing Single Nanoparticles
Published on: March 20, 2019
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The application of single molecule nanopore sensing for quantitative analysis
Yanfang Wu1, J Justin Gooding1
1School of Chemistry and Australian Centre for NanoMedicine, The University of New South Wales, Sydney, New South Wales 2052, Australia. yanfang.wu@unsw.edu.au.
Chemical Society Reviews
|May 4, 2022
Summary
Nanopore sensors enable single-molecule detection for quantitative analysis. This review explores nanopore sensor concepts, fabrication, and recent advancements for accurate analyte quantification.
Area of Science:
- Biophysics
- Nanoscience
- Analytical Chemistry
Background:
- Nanopore sensors detect molecules via conductance pulses during translocation.
- Single-molecule monitoring capability offers potential for quantitative sensing.
- Current applications focus on molecular identification.
Purpose of the Study:
- To review nanopore sensor concepts, fabrication, and sensing strategies.
- To highlight recent advances in quantitative nanopore sensing.
- To discuss future prospects and challenges in the field.
Main Methods:
- Review of existing literature on nanopore sensor technology.
- Classification and discussion of different nanopore types.
- Analysis of strategies for quantitative analyte detection.
Main Results:
- Nanopore sensors can be engineered for rapid and accurate quantification.
- Various strategies exist to enhance sensitivity and specificity.
- Pioneering studies demonstrate molecular identification capabilities.
Conclusions:
- Nanopore sensors are promising for quantitative analysis through single-molecule counting.
- Further research is needed to overcome challenges in sensitivity and throughput.
- Future prospects include improved device design and broader applications.
