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The Blood-brain Barrier

The Blood-brain Barrier

Physiological Barriers

Physiological Barriers

Physiological barriers are semi-permeable cellular structures restricting drug diffusion into intracellular compartments and tissues. There are six types of physiological barriers: blood endothelial, cell membrane, blood-brain, blood-cerebrospinal fluid (CSF), blood-placenta, and blood-testis barriers.
The blood endothelial barrier is the most porous of these. It allows all small ionized, un-ionized, and lipophilic molecules to pass through the endothelial lining into the interstitial space...

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Related Experiment Video

Updated: Sep 24, 2025

Rat Model of Blood-brain Barrier Disruption to Allow Targeted Neurovascular Therapeutics

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Published on: November 30, 2012

When the BBB goes MIA

Caroline A Pearson¹, Costantino Iadecola¹

¹Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY 10021.

Proceedings of the National Academy of Sciences of the United States of America

|May 4, 2022

Summary

No abstract available in PubMed .

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