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Related Concept Videos

Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

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Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
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Imaging Studies for Cardiovascular System V: CT01:28

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Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
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Imaging Studies for Cardiovascular System II:Types of Echocardiography01:20

Imaging Studies for Cardiovascular System II:Types of Echocardiography

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Echocardiography plays a role in assessing cardiac health and detecting heart conditions, with various types providing critical insights for diagnosis and treatment.
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Transthoracic Echocardiography (TTE)
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Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

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Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
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Related Experiment Video

Updated: Sep 24, 2025

Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice
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Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice

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A Pilot Study Comparing Aortic Sonography, Flow Cytometry, and Coronary CT.

Nicole Stigall-Weikle1,2, Kevin D Evans3,2, Isaiah W Bloom4,2

  • 1Nicole Stigall-Weikle, MS, RDMS, RVT, is associate director of the Laboratory for Investigatory Imaging.

Radiologic Technology
|May 4, 2022
PubMed
Summary

This study explored combining ultrasound aortic calcification, intimal thickness, and monocyte counts to predict cardiovascular disease (CVD) risk. This noninvasive approach shows promise for better CVD risk assessment than traditional methods.

Keywords:
aortaatherosclerosiscalcium scoringcardiovascular diseaseflow cytometry

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Area of Science:

  • Cardiovascular Disease Research
  • Medical Imaging Analysis
  • Immunology and Inflammation

Background:

  • Cardiovascular disease (CVD) risk prediction is crucial for preventative healthcare.
  • Current screening methods like computed tomography (CT) calcium scoring involve ionizing radiation.
  • There is a need for noninvasive and accessible CVD risk assessment tools.

Purpose of the Study:

  • To enhance cardiovascular disease (CVD) risk prediction by integrating multiple screening techniques.
  • To evaluate if combining sonographic aortic calcification, aortic intimal thickness, and monocyte laboratory values improves diagnostic detection compared to CT calcium scoring.

Main Methods:

  • A pre-experimental design was employed, collecting data from 11 volunteers (6 men, 5 women) aged 40-60.
  • Data included anthropometric measures, laboratory values, flow cytometry, coronary artery calcium (CAC) scores, atherosclerotic cardiovascular disease (ASCVD) 10-year risk scores, and aortic intimal-medial thickness (IMT).

Main Results:

  • Aortic IMT in different regions correlated significantly with mass, body mass index, ASCVD 10-year risk score, antihypertensive medications, and CAC.
  • Proportions of monocyte subsets (CD14+CD16- and CD14+CD16+) and expression of adhesion molecules (CD11a, CD11c) correlated with calcification in specific aortic regions.

Conclusions:

  • Sonography offers a nonionizing, noninvasive method for assessing CVD risk in clinical settings.
  • The combination of sonography and flow cytometry presents a promising alternative for CVD risk assessment.
  • Further research with larger, diverse populations is needed to refine CVD risk assessment strategies.