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Published on: December 23, 2016
Intelligent polymeric hydrogen sulfide delivery systems for therapeutic applications
Fan Rong1, Tengjiao Wang1, Qian Zhou1
1Frontiers Science Center for Flexible Electronics (FSCFE), Xi'an Institute of Flexible Electronics (IFE) & Xi'an Institute of Biomedical Materials and Engineering (IBME), Northwestern Polytechnical University (NPU), 127 West Youyi Road, Xi'an, Shaanxi, 710072, PR China.
Intelligent hydrogen sulfide (H2S) delivery systems offer precise therapeutic applications by responding to pathological conditions. These advanced systems enable targeted H2S release for various diseases, improving treatment efficacy.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Pharmacology
Background:
- Hydrogen sulfide (H2S) exhibits concentration-dependent physiological effects, with beneficial roles at low concentrations and detrimental effects at high doses.
- Precise control over H2S delivery is crucial for therapeutic applications, necessitating advanced delivery systems.
- Existing research highlights the potential of H2S in protecting cells, promoting regeneration, and regulating disease processes.
Purpose of the Study:
- To review the design, preparation, and therapeutic applications of intelligent polymeric H2S delivery systems.
- To highlight strategies for precise H2S therapies, including imaging-guided theranostics.
- To introduce the development of stimuli-responsive H2S donors for intelligent delivery systems.
Main Methods:
- Development of biocompatible polymeric systems for H2S delivery.
- Incorporation of targeting moieties and imaging capabilities into delivery systems.
- Design of H2S donors with stimuli-responsive characteristics.
Main Results:
- Intelligent polymeric H2S delivery systems demonstrate targeted delivery to lesions and responsiveness to pathological microenvironments.
- These systems allow for real-time monitoring of H2S delivery and lesion conditions.
- Applications in cardiovascular, inflammatory, regenerative, cancer, and bacteria-associated therapies are explored.
Conclusions:
- Intelligent polymeric H2S delivery systems represent a promising platform for precision medicine.
- Imaging-guided H2S theranostics offer enhanced therapeutic strategies.
- Further development of stimuli-responsive H2S donors is vital for advancing these systems.
