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Updated: Sep 24, 2025
Platelet-Rich Plasma Lysate for Treatment of Eye Surface Diseases
Published on: August 2, 2022
Platelet-rich plasma versus carboxytherapy in the treatment of periorbital dark circles: A split-face study
Samar M El-Tahlawi1, Marwa M Fawzy1, Zeinab El Maadawi2
1Department of Dermatology, Faculty of Medicine, Cairo University, Cairo, Egypt.
Background:
Periorbital hyperpigmentation is a recurrent problem in dermatologic clinics that affect the patients' quality of life and their psychological status. Platelet-rich plasma (PRP) may serve as a source of different growth factors which may reduce the pigmentation in this problem. Carboxytherapy is carbon dioxide infusion into human tissue for therapeutic purposes.
Objective:
To evaluate and compare the clinical efficacy of PRP and carboxytherapy in the treatment of periorbital dark circles (PODC). Histopathological evaluation was also done.
Patients And Methods:
Split-face study of 23 patients with PODC treated with PRP at the right side and carboxytherapy at the left side. Patients received four sessions; one session/week. Final follow-up evaluation was done 3 months after the last session by clinical and histopathological assessment.
Results:
PRP showed significant better response (p = 0.002), shorter downtime, and tolerable side effects than caboxytherapy. Reduction in area percent of melanin after PRP injections showed 46.6% improvement, while after carboxytherapy, it showed only 14.3% improvement.
Conclusion:
The present study showed that PRP is more effective and tolerable than caboxytherapy in the treatment of PODC.
