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New withanolides from Physalis minima and their cytotoxicity against A375 human melanoma cells
Meng Zhang1,2, Bingyang Zhang2, Chenxi Guang2
1School of Traditional Chinese Materia Medica, Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University Shenyang 110016 People's Republic of China fengqiu20070118@163.com syzyclx@163.com.
Abstract:
Seven previously undescribed withanolides, namely physaminilide A-G (1-7), and two artificial withanolides (8-9), along with 10 known analogues (10-19) were isolated from Physalis minima. The structures were established by spectroscopic analysis, including NMR and electronic circular dichroism (ECD) data. Cytotoxicity of all the isolates was evaluated against A375 human melanoma cells. Compounds 2, 5, 8, 10, 11 and 15 exhibited significant cytotoxic activities with IC50 values in the range of 1.2-9.4 μM.
