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Published on: January 23, 2019
Human pulmonary artery endothelial cells upregulate ACE2 expression in response to iron-regulatory elements:
Quezia K Toe1, Theo Issitt1,2, Abdul Mahomed1
1Cario-Respiratory Interface, National Heart Lung Institute Imperial College London London UK.
Abstract:
Vascular endothelial cell dysfunction is reported in severe coronavirus disease 2019 disease, however, controversy exists regarding levels of angiotensin-converting enzyme 2 (ACE2) expression, a coreceptor for severe acute respiratory syndrome coronavirus 2, in these cells. We report ACE2 expression and positive regulation by both interleuki-6, hepcidin, and ferroportin knock-down in pulmonary artery endothelial cells with potential implications for viral infection.
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