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Circular RNA SMARCA5 inhibits gastric cancer progression through targeting the miR-346/ FBXL2 axis

Quanying Li1, Hongna Tang1, Fangfang Hu1

  • 1Department of General Surgery, Huaihe Hospital of Henan University No. 8 of Baobei Road Kaifeng 475000 China hhyychangjiangqin@163.com +86-371-23906957 +86-371-23906957.

RSC Advances
|May 6, 2022
PubMed

Insights

Circular RNA SMARCA5 (circSMARCA5) acts as a tumor suppressor in gastric cancer. It inhibits proliferation, migration, and invasion by regulating the microRNA-346/FBXL2 pathway.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Circular RNA SMARCA5 (circSMARCA5) is implicated in various cancers.
  • Its specific role in gastric cancer remains uninvestigated.

Purpose of the Study:

  • To elucidate the function and underlying mechanism of circSMARCA5 in gastric cancer progression.

Main Methods:

  • Assessed circSMARCA5 expression in gastric cancer tissues and cell lines.
  • Performed in vitro experiments including cell proliferation, migration, and invasion assays.
  • Utilized luciferase reporter assays to identify interactions between circSMARCA5, miR-346, and FBXL2.

Main Results:

  • circSMARCA5 expression was significantly downregulated in gastric cancer.
  • Overexpression of circSMARCA5 suppressed gastric cancer cell proliferation, migration, and invasion.
  • circSMARCA5 functions as a molecular sponge for miR-346, thereby regulating FBXL2 expression.

Conclusions:

  • circSMARCA5 exhibits tumor suppressor activity in gastric cancer.
  • The circSMARCA5/miR-346/FBXL2 axis is a critical pathway in gastric cancer development.

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