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Updated: Sep 24, 2025

Synthesis of a Water-soluble Metal–Organic Complex Array
Published on: October 8, 2016
Mannich bases derived from lawsone and their metal complexes: synthetic strategies and biological properties
Abolfazl Olyaei1, Mahdieh Sadeghpour2, Mehdi Khalaj3
1Department of Chemistry, Payame Noor University (PNU) PO BOX 19395-4697 Tehran Iran olyaei_a@pnu.ac.ir.
Abstract:
Lawsone (2-hydroxynaphthalene-1,4-dione) is a natural product which shows significant biological activity. Aminomethylnaphthoquinone Mannich bases derived from lawsone constitute an interesting class of naphthoquinones and/or their metal complexes have demonstrated a series of important biological properties. So, this review aimed to document the publications concerning the synthesis of aminomethylnaphthoquinone Mannich bases from lowsone, aldehydes and amines and their metal complexes using different conditions, and investigation of their applications.
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