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Published on: June 21, 2021
Lipoic acid capped silver nanoparticles: a facile route to covalent protein capping and oxidative stability within
Irene Guzmán-Soto1, Mary Omole1, Emilio I Alarcon1,2
1Division of Cardiac Surgery, University of Ottawa Heart Institute 40 Ruskin Street Ottawa Canada ealarcon@ottawaheart.ca cmctiernan@ottawaheart.ca.
Abstract:
Covalent attachment of human serum albumin protein to the surface of spherical lipoic acid capped silver nanoparticles results in the generation of stable nanoparticle-protein hybrids with well defined surface composition. Enhanced stability towards oxidation and in the presence of complex media with high ionic strength, holds promise towards the use of these conjugates as therapeutics in biomedical applications and sensing.
