Construct indeno[1,2-b]oxepine or cis-cyclopropylacrylate by sulfur ylides
Qinfang Chen1, Yihao Pan1, Dongxin Zhao1
1School of Resources Environmental and Chemical Engineering, Nanchang University 999 XuFu Road Nangchang 330031 China Zhengjing@ncu.edu.cn.
Abstract:
For the first time, the [4 + 3] or [2 + 1] annulation of crotonate-derived sulfur ylides with arylidenemalononitrile or arylidene-1H-indene-1,3(2H)-dione is reported using Na2CO3 as the base. This protocol is advantageous as it does not require prior preparation of arylidenemalononitrile or arylidene-1H-indene-1,3(2H)-dione substrates, due to the independent participation of the base in the two reactions. This mild, operationally multicomponent process can be employed for the transformation of a wide variety of commercially available aldehydes into the corresponding indeno[1,2-b]oxepine or cyclopropyl acrylate core in moderate to excellent yields under mild conditions.
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