Fabrication of an (α-Mn₂O₃:Co)-decorated CNT highly sensitive screen printed electrode for the optimization and...

A new chemically optimized screen-printed electrode modified with a cobalt-doped α-Mn₂O₃ nanostructure on carbon nanotube paste (α-Mn₂O₃:Co@CNTs) has been constructed for the recognition of cyclobenzaprine hydrochloride. The prepared paste is based on the incorporation of oxide ion conductors, such as the α-Mn₂O₃ nanostructure with cobalt and ion pairs (tetraphenyl borate coupled with the drug), as electroactive species in the screen-printed electrode to increase the sensor surface area and decrease electrical resistance. The central composite design is a useful methodology for the estimation and modeling of the exact optimum parameters specifically designed for this process. This is a good way to graphically clarify the relationship between various experimental variables and the slope response. The proposed sensor, α-Mn₂O₃:Co@CNTs, possesses very good sensitivity and the ability to recognize the drug over the concentration range of 1 × 10^-6 to 1 × 10^-2 mol L^-1 at 25 ± °C with a detection limit of 2.84 × 10^-7 mol L^-1. It exhibits a reproducible potential and stable linear response for six months at a Nernstian slope of 58.96 ± 0.76 mV per decade. The proposed electrode approach has been successfully applied in the direct determination of the drug in its pure and dosage forms.