Co-delivery of chlorantraniliprole and avermectin with a polylactide microcapsule formulation

Area of Science:

• Agricultural Science
• Materials Science
• Environmental Science

Background:

• Improving pesticide formulations is crucial for reducing residues and environmental pollution.
• Co-delivery systems can enhance pesticide efficiency and decrease usage through synergistic effects.

Purpose of the Study:

• To develop a porous polylactide (PLA) microcapsule formulation for the co-delivery of avermectin (Av) and chlorantraniliprole (CAP).
• To evaluate the efficacy and stability of the co-delivery system against Plutella xylostella.

Main Methods:

• A double emulsion method combined with premix membrane emulsion (PME) was used to create porous microcapsules.
• The formulation was characterized for drug loading, entrapment efficiency, and stability.
• Biotoxicity assays were performed against Plutella xylostella.

Main Results:

• The developed porous microcapsules (Av/CAP P-MCs) demonstrated prolonged drug release, high loading content, and high entrapment efficiency.
• The formulation exhibited good light and thermal stability.
• Av/CAP P-MCs showed significantly higher biotoxicity against Plutella xylostella compared to single-pesticide formulations.

Conclusions:

• The co-delivery system of avermectin and chlorantraniliprole in porous PLA microcapsules is effective and stable.
• This formulation presents a promising, environmentally friendly approach for pest management.